Endocrine Abstracts

Introduction: Hyperthyroidism with diffuse goiter and negative TBII includes Graves’ disease in the early stage or near remission and nonautoimmune hyperthyroidism (NAH) caused by constitutively activating germline mutations of TSH receptor. To verify the NAH in this situation, we examined TSH receptor mutation and followed-up the clinical course.Patients and methods: From 2003 through 2011, 84 patients had hyperthyroidism with negative TBII and dif...

Objective: Serum thyroglobulin doubling time (Tg-DT/DR) is a valuable marker for predicting recurrences/metastases and response to treatment in patients with well-differentiated follicular cell-derived thyroid carcinoma. Similarly, tumor-volume doubling time/rate (TV-DT/DR) is helpful in predicting tumor progression during active surveillance of papillary microcarcinoma and chemotherapy. However, no study has investigated the clinical significance of Tg-DT/DR and TV-DT/DR in p...

More than half of patients with multiple endocrine neoplasia type 1 (MEN1) develop gastroenteropancreatic neuroendocrine tumors (GEPNETs). Among GEPNETs in MEN1, insulinoma is the second common functioning tumor and often diagnosed by its pathognomonic clinical feature, i.e. hypoglycemia. Compared to other functioning and nonfunctioning GEPNETs in MEN1, insulinoma is known to develop in younger age. We have recently constructed a database of Japanese patients with MEN1 and her...